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Optimized models for design of efficient miR30 based shRNAs

Aug 29, 2012 · Small hairpin RNAs (shRNAs) became an important research tool in cell biology. Reliable design of these molecules is essential for the needs of large functional genomics projects. To optimize the design of efficient shRNAs, we performed comparative, thermodynamic, and correlation analyses of ~18,000 miR30 based shRNAs with known functional efficiencies, derived from the Sensor Assay

Unusual inflammatory and fibrogenic pulmonary responses

A standard curve was established by addition of GSH (0.044.0 M) to 100 mM disodium phosphate buffer (pH 7.4) containing 10 M ThioGlo 1 (DMSO solution). A spectrofluorophotometer RF 5301PC (Shimadzu, Kyoto, Japan) was employed for the assay of fluorescence using excitation at 388 nm and emission at 500 nm.

Case Studies in Environmental Medicine NCBI Bookshelf

This appendix contains 55 case studies from peer reviewed literature, including journal articles and educational material developed by the Agency for Toxic Substances and Disease Registry (ATSDR). They were selected for their clinical interest with respect to environmental factors and health, relevance to particular courses and clerkships in medical school, and illustrative potential for


The physiologic basis for this outcome is unclear, but it was reported that animals exposed to high doses of aluminium in drinking water consumed less food. Whether general effects of aluminium on metabolic processes depress metabolism or reduce nutritional efficiency remains to be resolved.

Nitenpyram C11H15ClN4O2 PubChem

Nitenpyram is a C nitro compound consisting of 2 nitroethene 1,1 diamine where one of the nitrogens bears ethyl and (6 chloro 3 pyridinyl)methyl while the other nitrogen carries a methyl group. It has a role as a neonicotinoid insectide. It is a C nitro compound and

Clindamycin C18H33ClN2O5S PubChem

Clindamycin is used as an alternative agent for prevention of a hemolytic (viridans group) streptococcal bacterial endocarditis in penicillin allergic adults and children with certain cardiac conditions who are undergoing certain dental procedures (i.e., procedures that involve manipulation of gingival tissue, the periapical region of teeth, or perforation of oral mucosa) or certain invasive

1,4 Dichlorobenzene C6H4Cl2 PubChem

Data on the potential for 1,4 dichlorobenzene to cause cancer in humans were not available. Liver tumors were induced in laboratory animals following lifetime exposure to high levels of 1,4 dichlorobenzene in the air or water. Leukemia as well as liver, kidney, and adrenal gland tumors were observed in laboratory animals following lifetime oral

Ciprofloxacin C17H18FN3O3 PubChem

Ciprofloxacin is a quinolone that is quinolin 4(1H) one bearing cyclopropyl, carboxylic acid, fluoro and piperazin 1 yl substituents at positions 1, 3, 6 and 7, respectively. It has a role as an antiinfective agent, a topoisomerase IV inhibitor, an antibacterial drug, an EC [DNA topoisomerase (ATP hydrolysing)] inhibitor, a DNA synthesis inhibitor, an antimicrobial agent, an

Climate drivers of the terrestrial carbon cycle

The terrestrial biosphere is a key component of the global carbon cycle and is heavily influenced by climate. Climate variability can be diagnosed through metrics ranging from individual environmental variables, to collections of variables, to the so called climate modes of variability.

Radioactive Wounds of War In These Times

Aug 25, 2005 · Radioactive Wounds of War. Standard tactic these days. It is you who wants to change the subject and avoid whether the 'dose' is being properly measured. and a very find dust

FungicidesAn Overlooked Pesticide Class? Environmental

Fungicides are indispensable to global food security and their use is forecasted to intensify. Fungicides can reach aquatic ecosystems and occur in surface water bodies in agricultural catchments throughout the entire growing season due to their frequent, prophylactic application. However, in comparison to herbicides and insecticides, the exposure to and effects of fungicides have received

Sensing technologies for precision specialty crop production

Sensing technologies for precision specialty crop production. High resolution remote sensing imagery has the potential for yield estimation for specialty crops. Application of machine vision in agriculture is enhanced by the use of task specific wavelengths in the visible and beyond the visible spectrum range, leading to more successfully

Free Access to Scientific Journals Open Access Journals

Open Access journals are the major source of knowledge for young and aspiring generations who are keen in pursuing a career in sciences. This system provides easy access to networks of scientific journals.Authors that contribute their scholarly works to Open Access journals gain remarkable reputation as the research scholarly explore these works extensively.


definition of senses, usage, synonyms, thesaurus. Online DictionariesDefinition of Options|Tips Options|Tips

White spirit (EHC 187, 1996) INCHEM

White spirit is readily absorbed following inhalation exposure. The inhalation absorption of white spirit depends on several factors including concentration in the inspired air, blood partition coefficient, pulmonary ventilation and pulmonary blood flow. White spirit

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A powerful, streamlined new Astrophysics Data System astrophysics data system loading 25% Complete Downloading Assets. Loading ADS Load basic HTML (for slow connections/low resources)

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